Societal cohesion is increasingly important for successful sustainable cities to be healthy. Health can also benefit, in part, by improving medical and preventative care, as is the mission of programs in medicine, nursing, and public health at all three University of Illinois campuses. But human health is also shaped by features of the urban environment. Health is affected by food security and the quality of the food people consume. Health depends on environmental conditions, such as pollution and heat. And health depends on stress and physical activity, which in turn are shaped by transportation networks, crime levels, and access to nature as well as open space for recreation. CURES will develop multi-prong strategies to help urban areas become healthy cities.