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Multimodal data is combined with pristine, spatially-linked human brain tissues housed in the UI NeuroRepository enabling an expansive systems biology approach that unites clinical, imaging, and electrical brain activity with the underlying cells, genes, proteins, and molecules that contribute to disease. Combining integrated data with an artificial intelligence-based analysis contributes to a better understanding of the human brain and has led to a pipeline of new diagnostics and therapeutics to combat brain disorders.


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Project Director/PI

Jeffrey Loeb

University of Illinois at Chicago: Professor, Neurology


Project Lead

Biswajit Maharathi

University of Illinois at Chicago: Senior Research Specialist, Neurology and Rehabilitation Medicine


Strategic Technology Architect

Narciso Albarracin

ONTOADAPTIVE: Strategic Technology Architect

Kevin Donnell 202x202

Business and Workforce Development

Kevin Donnelly


Scientific Advisory Team:

Ravi Iyer, Brain signal processing, AI, system biology

James Patton, Brain Signal Processing

Elisabeta Marai, Brain Visualization and Imaging

Ed Barbour, Systems Biology, Analytics, AI/ML

Eugene Sadhu, Informatics Architecture


A unique integrated health informatics system designed for improved clinical intervention and research.

INTUITION  combines digital data including health records, radiology, electrophysiology, with precisely-mapped human brain tissues and all downstream Information from that tissue including histology, genomics, proteomics, and metabolomics.

INTUITION   uses integrated system biology with AI-driven data analytics to generate a more complete understanding of human brain disorders leading to better patient care and new treatments.

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Multimodal data is brought together in a single platform to accelerate research

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End-to-End secure patient-centric data collection and analytics pipeline

I-BRAIN Team in the News

After You Die, Zombie Genes in Your Brain Come to Life

Popular Mechanics

Here’s some fun news: After you die, you’re not completely dead. In a new study, scientists from the University of Illinois–Chicago reveal that some genes express more actively in the human brain after death.

How do these “zombie genes” still hang around, exactly? The answer is a combination of common sense and surprise.

To study the postmortem brain, researchers collected brain tissue samples from brain surgery patients. In Scientific Reports, they write…

Tablet-based tool helps epilepsy patients learn self-management skills

UIC News

Epilepsy patients who want to learn how to manage their own unique symptoms can now get individualized information via tablet computer through a research project at the University of Illinois at Chicago.

“PAUSE” — for Personalized Internet Assisted Underserved Self-management for Epilepsy — is a tablet-based tool customized for each patient to help them stay healthy and reduce the need for emergency services.

Neurological tissue bank to help uncover new cures

UIC News

UIC celebrated the opening of a unique human brain and neural tissue bank and big-data center that will help scientists uncover new cures for diseases like epilepsy, ALS and brain tumors.

The University of Illinois NeuroRepository will house tissue samples from patients treated for neurological disorders at the University of Illinois Hospital.

Epilepsy biomarkers pave way for noninvasive diagnosis, better treatments

UIC News

Researchers have identified a unique metabolic signature associated with epileptic brain tissue that causes seizures. The chemical biomarker can be detected noninvasively using technology based on magnetic resonance imaging. It will allow physicians to precisely identify small regions of abnormal brain tissue in early-stage epilepsy patients that can’t be detected today using current technology.

Epileptics in high-crime neighborhoods have three times as many seizures

UIC News

People with epilepsy living in high crime neighborhoods in Chicago had three times as many seizures as those living in neighborhoods with lower crime rates, according to new research from the University of Illinois at Chicago presented at the American Epilepsy Society 2018 conference in New Orleans.

Can a nerve injury trigger ALS?

UIC News

A growing collection of anecdotal stories raises the possibility that nerve injury in an arm or a leg can act as a trigger for the development amyotrophic lateral sclerosis, or ALS — a progressive neurodegenerative disease also known as Lou Gehrig’s disease, named after the famous New York Yankee who died of it in 1941.